Sample Preparation and Nucleic Acid Extraction Markets 2027–2031

Sample Preparation and Nucleic Acid Extraction Markets: Market Forecast, Competitive Landscape, Company Revenue Estimates, Technology and World Metropolitan Area Market Sizes, 2027–2031

Global forecasts of sample preparation and nucleic acid extraction revenue by product, technology, sample type, application and customer, for 14 countries and regions and 237 metropolitan areas, with 38 company profiles. Extraction and purification kits, automated extraction instruments, sample collection and stabilisation, NGS library preparation, and plastics, consumables and service.

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Our Take

Every molecular test starts with a sample. Before a PCR instrument or sequencer can read it, the nucleic acid has to be collected, stabilised, extracted and prepared, and that work is moving from manual columns to automated magnetic beads, and in some workflows is being skipped altogether. Library preparation is the largest product line, and liquid biopsy is pulling demand toward blood and cfDNA. The market grows from $6,150.0 million in 2026 to $8,150.0 million in 2031, at 5.8% a year.

Market Size 2026: USD $6,150.0M Market Size 2031: USD $8,150.0M CAGR: 5.8%

Situation Analysis: what is really happening

• Beads win, columns fade. Magnetic Bead methods grow 7.0% a year and rise from 55.0% to 58.3% of the market as laboratories automate, while Silica Column & Membrane grows 0.8% a year and falls from 19.6% to 15.4%.
• Skipping the step. Direct & Extraction-Free methods are the fastest-growing technology at 15.2% a year, from 6.0% to 9.2% of the market, as direct PCR and library preparation on the sequencer remove steps.
• Liquid biopsy pulls the sample. Oncology & Liquid Biopsy is the fastest-growing application at 9.9% a year, rising from 19.0% to 23.0%, and Blood, Plasma & cfDNA grows 8.5% a year.
• Library prep leads. NGS Library Preparation is the largest product line, rising from 37.1% to 39.0% of the market, while Automated Extraction Instruments grow 3.1% a year as the installed base matures.
• Clinical laboratories are the core. Hospital & Reference Labs grow 6.9% a year to 49.6% of the market, while Academic & Government Research grows 3.2%.
• New owners and falling prices. EQT agreed a business combination with QIAGEN, Waters completed its combination with BD Biosciences & Diagnostic Solutions, and Kehua Bio reported a third year of losses as Chinese molecular prices fell. China is the fastest-growing country, at $739.3 million in 2026 and 10.6% a year.

Company Analysis: who is positioned, who is exposed

• Agilent Technologies, Bio-Rad Laboratories, Danaher (Beckman Coulter Life Sciences, IDT), Illumina, QIAGEN, Revvity, Roche Diagnostics and Thermo Fisher Scientific: Platform, kit and library preparation suppliers, with HSR’s estimates of each company’s sample preparation revenue and ranges.
• Analytik Jena (Endress+Hauser), Macherey-Nagel, MagBio Genomics, New England Biolabs, Norgen Biotek, Omega Bio-tek, Promega and Zymo Research: Extraction kit and chemistry specialists.
• Copan, Longhorn Vaccines & Diagnostics, OraSure Technologies (DNA Genotek), PreAnalytiX, Puritan Medical Products, Streck and Waters: Sample collection, transport and stabilisation.
• Covaris, Lexogen, Pacific Biosciences and Oxford Nanopore Technologies, Takara Bio, Twist Bioscience and Watchmaker Genomics: Library preparation and long-read sample preparation.
• Hamilton Company and Tecan: Liquid handling and automation.
• Bioer Technology, Hangzhou Allsheng Instruments, MGI Tech, Sansure Biotech, Tianlong Technology (Kehua Bio), Vazyme Biotech and Yeasen Biotechnology: China’s instrument and reagent makers.

In all, 38 company profiles, each one to two pages with a fact box covering website, headquarters, ownership, revenue, employees and key products.

Inside the report: HSR’s revenue estimate for every named company, with low–high ranges, and a growth and share-change map of every application and technology line. Names and values are in the full report.

Questions this report answers

• How large is the sample preparation and nucleic acid extraction market, and how fast will it grow?
• How much sample preparation revenue do Thermo Fisher, QIAGEN, Illumina, Roche and other suppliers earn?
• How fast are magnetic beads and extraction-free methods replacing columns?
• How much will liquid biopsy and library preparation add, and which sample types grow fastest?
• What do FDA, IVDR and NMPA rules and China’s price competition mean for suppliers?
• How large is each country market, and which metropolitan areas lead?

What's inside

• 411 pages, 23 chapters, 124 tables and 60 figures
• Forecasts for 2027–2031 from a 2026 base year, by product, technology, sample type, application and customer, for 14 countries and regions
• Market sizes for 237 world metropolitan areas in 2026 and 2031, with the top 30 and fastest-growing metros
• How sample preparation works; products, technologies, sample types, applications and customers; technology trends; IVD – The Big Picture
• Regulation and quality; 10 market-moving developments; competitive landscape with company revenue estimates, SWOT, Porter's Five Forces and strategic recommendations
• 38 company profiles
• Download the Table of Contents (PDF)

Who buys this report

• Kit, instrument and collection device suppliers: size target segments by product, technology, sample type and customer, and benchmark competitors.
• Sequencing and molecular diagnostics companies: plan library preparation and front-end workflow partnerships.
• Clinical and research laboratories: plan automation and the move to extraction-free workflows.
• Investors: assess consolidation, new owners and growth.

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ABOUT THE LEAD AUTHOR

Mr. Greg Powell, B.SC., M.B.A is the President of Howe Sound Research. His education includes:

Finance for Senior Executives - Harvard Business School

Market Research - Burke Institute

M.B.A. (Finance and Policy) - University of British Columbia

B.Sc. (Chemistry) - University of British Columbia

He is an experienced business and clinical professional. He is co-author of the paper "The Radioimmunoassay of Angiotensinogen by Antibody Trapping." He has worked in laboratory testing and management for over 20 years.